2026

  1. Cummings, J.A., Majumdar, S., Bishara, A., Motzkin, J., Raj, A., Shirvalkar, P., Lotz, J., 2026. Predicting pain location from resting-state brain fMRI. bioRxiv. https://doi.org/10.64898/2026.06.14.732139.

  2. Leriche, R.B., Wozny, T.A., Saal, J., Motzkin, J.C., Sellers, K.K., Starr, P.A., Chang, E.F., Shirvalkar, P., 2026. Human intracranial signal stability tracks anatomical accuracy after electrode reimplantation. J. Neural Eng. 23, 046019. https://doi.org/10.1088/1741-2552/ae805e.

  3. Motzkin, J.C., He, B., Gupta, K., Shirvalkar, P., 2026. Chronic Pain Is a Brain Network Disorder. JAMA Neurology 83, 205–206. https://doi.org/10.1001/jamaneurol.2025.5065.

  4. Saal, J., Khambhati, A.N., Chang, E.F., Shirvalkar, P., 2026. Decoding Chronic Pain States from Distributed Intracranial Recordings. bioRxiv. https://doi.org/10.64898/2026.06.16.732555.

  5. Starkweather, C.K., Willbrand, E.H., Sellers, K.K., Hullet, P., Krystal, A.D., Shirvalkar, P., Weiner, K.S., Willie, J.T., Brunner, P., Chang, E.F., Knight, R.T., 2026. Rapid homotopic communication between human orbitofrontal subregions. Current Biology 36, 1556-1561.e2. https://doi.org/10.1016/j.cub.2026.01.076.

  6. Thrash, G.W., Wang, E., Brockington, D., Rives, C., Sun, Y., Roberts, A.C., Das, S., Pilitsis, J.G., Shirvalkar, P., Do Campo, R.V., Walker, H.C., Earley, C.J., Holland, M.T., 2026. Neuromodulation for Restless Legs Syndrome: A Systematic Review and Mechanistic Considerations for Spinal Cord Stimulation. Sleep Breath 30, 83. https://doi.org/10.1007/s11325-026-03638-7.

2025

  1. Ciampi De Andrade, D., Shirvalkar, P., 2025. The future of pain research: neuromodulation and surgery. Pain 166, S116–S120. https://doi.org/10.1097/j.pain.0000000000003662.

  2. Holland, M.T., Mekhail, M.N., Thrash, G., George, T., Mugan, D., Paul, C., Shirvalkar, P., Grace, W., Deer, T., McGregor, K., Vazquez Do Campo, R., Earley, C.J., Walker, H.C., 2025. Adaptive spinal cord stimulation improves restless legs syndrome: Case report, literature review, and mechanistic hypothesis. Sleep Medicine 134, 106664. https://doi.org/10.1016/j.sleep.2025.106664.

  3. Saal, J., Kadlec, K., Allawala, A.B., Johnston, L., Leriche, R.B., Vatsyayan, R., Han, Y., Kist, A., Di Ianni, T., Dawes, H.E., Chang, E.F., Lee, A.M., Krystal, A.D., Moussawi, K., Shirvalkar, P., Sellers, K.K., 2026a. Toward Individualized Deep Brain Stimulation: A Stereoelectroencephalography-Based Workflow for Neurostimulation Target Identification. Neuromodulation: Technology at the Neural Interface 29, 483–491. https://doi.org/10.1016/j.neurom.2025.11.006.

  4. Shirvalkar, P., Rozell, C.J., 2025. Brain Biomarkers for Pain Sensitivity. JAMA Neurol 82, 216. https://doi.org/10.1001/jamaneurol.2024.4743

  5. Shirvalkar, P., Bs, R.L., Saal, J., Cagle, J., Ma, J.P., Bs, I.J., Shaughnessy, A., Schmitgen, A., Lin, J., Motzkin, J., Dawes, H., Racine, C., Seritan, A., Sellers, K.K., 2025. Personalized, closed-loop deep brain stimulation for chronic pain. medRxiv. https://doi.org/https://doi.org/10.1101/2025.08.11.25333010

2024

  1. Saal, J., Khambhati, A.N., Chang, E.F., Shirvalkar, P., 2024. Robust Detection of Brain Stimulation Artifacts in iEEG Using Autoencoder-Generated Signals and ResNet Classification. bioRxiv https://doi.org/10.1101/2024.09.30.615930.

  2. Thrash, G.W., Wang, E., Sun, Y., Walker, H.C., Shirvalkar, P., Becker, B.K., Holland, M.T., 2024. Clinical trials in neuromodulatory treatment of drug-resistant hypertension and the need for spinal cord stimulation trials: a PRISMA systematic review. Bioelectron Med 10, 28. https://doi.org/10.1186/s42234-024-00160-7.

  3. Shukla, P.D., Burke, J.F., Kunwar, N., Presbrey, K., Balakid, J., Yaroshinsky, M., Louie, K., Jacques, L., Shirvalkar, P., Wang, D.D., 2024. Human Cervical Epidural Spinal Electrogram Topographically Maps Distinct Volitional Movements. J. Neurosci. 44, e2258232024. https://doi.org/10.1523/JNEUROSCI.2258-23.2024.

  4. Shirvalkar, P., Starr, P.A., Chang, E.F., 2024. Ambulatory Brain Biomarkers of Chronic Pain: Towards Closed Loop Brain Stimulation. Biological Psychiatry 95, S24. https://doi.org/10.1016/j.biopsych.2024.02.062.

2023

  1. Motzkin, J.C., Kanungo, I., D’Esposito, M., Shirvalkar, P., 2023. Network targets for therapeutic brain stimulation: towards personalized therapy for pain. Front. Pain Res. 4, 1156108. https://doi.org/10.3389/fpain.2023.1156108.

  2. Shirvalkar, P., Poree, L., 2023. How SAFE Is Real-world Use of Spinal Cord Stimulation Therapy for Chronic Pain? JAMA Neurol 80, 10. https://doi.org/10.1001/jamaneurol.2022.3471.

  3. Shirvalkar, P., Prosky, J., Chin, G., Ahmadipour, P., Sani, O.G., Desai, M., Schmitgen, A., Dawes, H., Shanechi, M.M., Starr, P.A., Chang, E.F., 2023. First-in-human prediction of chronic pain state using intracranial neural biomarkers. Nat Neurosci 26, 1090–1099. https://doi.org/10.1038/s41593-023-01338-z.

  4. Staudt, M.D., Yaghi, N.K., Mazur-Hart, D.J., Shirvalkar, P., 2023. Editorial: Advancements in deep brain stimulation for chronic pain control. Front. Pain Res. 4, 1293919. https://doi.org/10.3389/fpain.2023.1293919.

2022

  1. Wong, J.K., Deuschl, G., Wolke, R., Bergman, H., Muthuraman, M., Groppa, S., Sheth, S.A., Bronte-Stewart, H.M., Wilkins, K.B., Petrucci, M.N., Lambert, E., Kehnemouyi, Y., Starr, P.A., Little, S., Anso, J., Gilron, R., Poree, L., Kalamangalam, G.P., Worrell, G.A., Miller, K.J., Schiff, N.D., Butson, C.R., Henderson, J.M., Judy, J.W., Ramirez-Zamora, A., Foote, K.D., Silburn, P.A., Li, L., Oyama, G., Kamo, H., Sekimoto, S., Hattori, N., Giordano, J.J., DiEuliis, D., Shook, J.R., Doughtery, D.D., Widge, A.S., Mayberg, H.S., Cha, J., Choi, K., Heisig, S., Obatusin, M., Opri, E., Kaufman, S.B., Shirvalkar, P., Rozell, C.J., Alagapan, S., Raike, R.S., Bokil, H., Green, D., Okun, M.S., 2022. Proceedings of the Ninth Annual Deep Brain Stimulation Think Tank: Advances in Cutting Edge Technologies, Artificial Intelligence, Neuromodulation, Neuroethics, Pain, Interventional Psychiatry, Epilepsy, and Traumatic Brain Injury. Front. Hum. Neurosci. 16, 813387. https://doi.org/10.3389/fnhum.2022.813387.

2021

  1. Burke, J.F., Kunwar, N., Yaroshinsky, M.S., Louie, K.H., Shirvalkar, P., Su, P., Henry, M., Pasvankas, G., Poree, L., Jacques, L., Wang, D.D., 2021. Epidural Spinal Electrogram Provides Direct Spinal Recordings in Awake Human Participants. Front. Hum. Neurosci. 15, 721076. https://doi.org/10.3389/fnhum.2021.721076.

  2. Prosky, J., Cagle, J., Sellers, K.K., Gilron, R., De Hemptinne, C., Schmitgen, A., Starr, P.A., Chang, E.F., Shirvalkar, P., 2021. Practical Closed-Loop Strategies for Deep Brain Stimulation: Lessons From Chronic Pain. Front. Neurosci. 15, 762097. https://doi.org/10.3389/fnins.2021.762097.

  3. Schmitgen, A., Saal, J., Sankaran, N., Desai, M., Joseph, I., Starr, P., Chang, E.F., Shirvalkar, P., 2021. Musical Hallucinations in Chronic Pain: The Anterior Cingulate Cortex Regulates Internally Generated Percepts. Front. Neurol. 12, 669172. https://doi.org/10.3389/fneur.2021.669172.

  4. Sellers, K.K., Gilron, R., Anso, J., Louie, K.H., Shirvalkar, P.R., Chang, E.F., Little, S.J., Starr, P.A., 2021. Analysis-rcs-data: Open-Source Toolbox for the Ingestion, Time-Alignment, and Visualization of Sense and Stimulation Data From the Medtronic Summit RC+S System. Front. Hum. Neurosci. 15, 714256. https://doi.org/10.3389/fnhum.2021.714256.

  5. Shirvalkar, P., Sellers, K.K., Schmitgen, A., Prosky, J., Joseph, I., Starr, P.A., Chang, E.F., 2020. A Deep Brain Stimulation Trial Period for Treating Chronic Pain. JCM 9, 3155. https://doi.org/10.3390/jcm9103155.

  6. Tom, W.R., Pham, T.M., Shirvalkar, P., 2021. A Tale of Two Cords: Diastematomyelia. Pain Medicine 22, 1000–1001. https://doi.org/10.1093/pm/pnab026.