Adaptive Deep Brain Stimulation for Refractory Chronic Pain
We study chronic pain as a network-level brain disorder and develop closed-loop therapies using established Deep Brain Stimulation (DBS) technologies to provide effective and lasting relief.
Acute Pain Processing Pathways
Most research on pain in the brain has focused on short-term, experimental pain. Our work shows that chronic pain relies on different brain circuits and rhythms, highlighting the need to study mechanisms unique to chronic pain.
Biomarkers of Detecting Chronic Pain
Biomarkers of spontaneous chronic pain are distributed across multiple networks within the brain. We demonstrate that the multi-region neural dynamics encoding chronic pain can be tracked using multi-site intracranial recording over a ten-day hospital stay; these analyses can then inform personalized electrode placement to be used in long-term closed-loop deep brain stimulation.